Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | REN | P00797 | 16/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | CTSE | P14091 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520875 | 0.92 | CTSS (0.52) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7267275 | 0.92 | CTSS (0.52) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7297295 | 0.90 | CTSS (0.52) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL6448979 | 0.90 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL9848334 | 0.90 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL8536013 | 0.90 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7329863 | 0.89 | REN (0.54) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7284721 | 0.88 | CTSS (0.55) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7266599 | 0.86 | REN (0.58) | CTSSCTSKREN | |
| SCHEMBL6696371 | 0.86 | REN (0.58) | CTSSCTSKREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346887-A | Mixture of tripeptide renin inhibitor and steroid antiinflammatory agent | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0483271-B1 | PEPTIDES CONTAINING DIAMINO-GLYCOLS AS TRANSITION-STATE MIMICS | THE UPJOHN COMPANY (US) | 1993-08-25 | — | — | EP | disclosed |
| WO-1992006996-A1 | PEPTIDES CONTAINING SUBSTITUTED 1,4-DIAMINES AS TRANSITION-STATE INSERTS | THE UPJOHN COMPANY (US) | 1992-04-30 | — | — | WO | disclosed |
| US-5059589-A | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1991-10-22 | — | — | US | disclosed |
| US-5036051-A | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-07-30 | — | — | US | disclosed |
| WO-1991001327-A1 | PEPTIDES CONTAINING DIAMINO-GLYCOLS AS TRANSITION-STATE MIMICS | THE UPJOHN COMPANY (US) | 1991-02-07 | — | — | WO | disclosed |
| US-4977277-A | INTERMEDIATES FOR RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-12-11 | — | — | US | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0311012-A2 | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1989-04-12 | — | — | EP | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |