Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.32 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.65 |
| ▸ | HTR3B | O95264 | 2/20 | 0.65 |
| ▸ | HTR3A | P46098 | 2/20 | 0.65 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.65 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.65 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.32 |
| ▸ | WNT3A | P56704 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 2/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286830 | 0.94 | HTR3A (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Maleic Acid SCHEMBL7324754 | 0.86 | HTR3A (0.88) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Fumaric Acid SCHEMBL7324761 | 0.86 | HTR3A (0.88) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Maleic Acid SCHEMBL7298744 | 0.82 | HTR3E (0.52) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Fumaric Acid SCHEMBL7298751 | 0.82 | HTR3E (0.52) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Maleic Acid SCHEMBL7272911 | 0.81 | HTR3E (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Maleic Acid SCHEMBL7274919 | 0.81 | HTR3A (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Maleic Acid SCHEMBL9655781 | 0.79 | HTR3A (0.66) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Maleic Acid SCHEMBL7265485 | 0.79 | GABRR1 (0.41) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Fumaric Acid SCHEMBL7265493 | 0.79 | GABRR1 (0.41) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4808581-A | ANXIOLYTIC, ANTIEMETIC, TREATMENT OF PSYCHOLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1989-02-28 | — | — | US | disclosed |
| EP-0276163-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1988-07-27 | — | — | EP | disclosed |