Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275441 | 0.89 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1NPC1CNR1 | |
| SCHEMBL7265568 | 0.88 | HPGD (0.52) | ALDH1A1KMT2APKMLMNATSHR | |
| SCHEMBL7273433 | 0.88 | GAA (0.61) | HRH3ALDH1A1GAAPKMSMN1; SMN2 | |
| SCHEMBL1237539 | 0.85 | LMNA (0.55) | HRH3ALDH1A1KMT2AGAASMN1; SMN2 | |
| SCHEMBL1804892 | 0.85 | LMNA (0.55) | HRH3ALDH1A1KMT2AGAASMN1; SMN2 | |
| SCHEMBL7266943 | 0.85 | DPP4 (0.56) | HRH3ALDH1A1KMT2AGAALMNA | |
| SCHEMBL9726960 | 0.83 | DPP4 (0.47) | ALDH1A1GAASMN1; SMN2LMNATSHR | |
| SCHEMBL7271931 | 0.83 | KCNH2 (0.53) | HRH3 | |
| SCHEMBL7278569 | 0.82 | KMT2A (0.49) | HRH3ALDH1A1KMT2AGAASMN1; SMN2 | |
| SCHEMBL10425827 | 0.82 | HPGD (0.51) | HRH3ALDH1A1KMT2AGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | claimed |
| EP-0268190-B1 | PROLINAL DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | claimed |
| EP-0268190-A1 | Prolinal derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-05-25 | — | — | EP | claimed |
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| US-5100904-A | Inhibition of prolyl endopeptidase | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-03-31 | — | — | US | disclosed |
| US-4956380-A | COGNITION ACTIVATORS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-09-11 | — | — | US | disclosed |