Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267256 | 0.88 | HRH3 (0.53) | GAAHRH3ALDH1A1LMNAPKM | |
| SCHEMBL7267106 | 0.85 | TP53 (0.59) | ALDH1A1LMNAHTTPOLBMAPT | |
| SCHEMBL7266943 | 0.84 | DPP4 (0.56) | GAAHRH3ALDH1A1LMNA | |
| SCHEMBL7275293 | 0.82 | LMNA (0.45) | GAALMNAMAPT | |
| SCHEMBL7265568 | 0.80 | HPGD (0.52) | ALDH1A1EPHX2LMNAPKMHPGD | |
| SCHEMBL7275441 | 0.80 | ALDH1A1 (0.50) | ALDH1A1POLB | |
| SCHEMBL7272118 | 0.80 | KDM4E (0.52) | GAAALDH1A1PKMHTTHPGD | |
| SCHEMBL7267027 | 0.79 | HRH3 (0.53) | HRH3EPHX2LMNAMAPT | |
| SCHEMBL7272291 | 0.78 | MEN1 (0.55) | GAAHRH3ALDH1A1EPHX2LMNA | |
| SCHEMBL1804892 | 0.78 | LMNA (0.55) | GAAHRH3ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | claimed |
| EP-0268190-B1 | PROLINAL DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | claimed |
| EP-0268190-A1 | Prolinal derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-05-25 | — | — | EP | claimed |
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| US-5100904-A | Inhibition of prolyl endopeptidase | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-03-31 | — | — | US | disclosed |
| US-4956380-A | COGNITION ACTIVATORS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-09-11 | — | — | US | disclosed |