Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 6/20 | 0.44 |
| ▸ | DRD4 | P21917 | 5/20 | 0.44 |
| ▸ | DRD3 | P35462 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268521 | 0.91 | ADRA1D (0.50) | HTR7MAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL8723945 | 0.85 | ADRA1D (0.59) | KDM4EADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL9405381 | 0.82 | MEN1 (0.48) | HTR7MAPTKDM4ETSHR | |
| SCHEMBL7268609 | 0.80 | HTR7 (0.46) | HTR7MAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL7267422 | 0.76 | HTR7 (0.42) | HTR7MAPTKDM4EALDH1A1ALOX15 | |
| Mefeclorazine SCHEMBL2110367 | 0.74 | ADRA1D (0.73) | KDM4EALDH1A1ADRA1DADRA1AADRA1B | |
| SCHEMBL7269688 | 0.72 | KDM4E (0.52) | HTR7KDM4EALDH1A1ALOX15TSHR | |
| SCHEMBL2785351 | 0.72 | DRD2 (0.54) | KDM4EALDH1A1DRD2DRD3HTR1A | |
| SCHEMBL2783222 | 0.70 | DRD2 (0.75) | KDM4EALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL27410454 | 0.70 | MEN1 (0.46) | HTR7MAPTKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624584-B1 | Piperazine derivatives useful as calmodulin inhibitors | DAIICHI SEIYAKU CO (JP) | 1998-08-19 | — | — | EP | claimed |
| US-6596706-B1 | For the treatment of circulatory diseases cerebral diseases | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |
| EP-1029872-A1 | PIPERAZINE-CYCLODEXTRIN COMPLEXES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-08-23 | — | — | EP | disclosed |
| EP-0624584-B1 | Piperazine derivatives useful as calmodulin inhibitors | DAIICHI SEIYAKU CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| EP-0624584-A1 | Piperazine derivatives useful as calmodolin inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-11-17 | — | — | EP | disclosed |