Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.53 |
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7267622 | 1.00 | TAAR1 (0.53) | TAAR1SLC6A2HIF1ASMN1; SMN2CYP1A2 | |
| Maleic Acid SCHEMBL8866450 | 0.91 | SLC6A2 (0.47) | TAAR1SLC6A2HIF1ASMN1; SMN2CYP1A2 | |
| Fumaric Acid SCHEMBL8866470 | 0.91 | SLC6A2 (0.47) | TAAR1SLC6A2HIF1ASMN1; SMN2CYP1A2 | |
| Maleic Acid SCHEMBL8866306 | 0.90 | SLC6A2 (0.51) | TAAR1SLC6A2HIF1ASMN1; SMN2CYP1A2 | |
| Maleic Acid SCHEMBL8976052 | 0.90 | PPARG (0.51) | TAAR1SLC6A2HIF1ASMN1; SMN2CYP1A2 | |
| Fumaric Acid SCHEMBL8866320 | 0.90 | SLC6A2 (0.51) | TAAR1SLC6A2HIF1ASMN1; SMN2CYP1A2 | |
| Fumaric Acid SCHEMBL8865758 | 0.90 | PPARG (0.51) | TAAR1SLC6A2HIF1ASMN1; SMN2CYP1A2 | |
| Fumaric Acid SCHEMBL8867443 | 0.87 | ALDH1A1 (0.48) | TAAR1SMN1; SMN2MAPK1ALDH1A1LMNA | |
| Maleic Acid SCHEMBL8866047 | 0.87 | MMP1 (0.47) | TAAR1SLC6A2MAPK1ALDH1A1KMT2A | |
| Fumaric Acid SCHEMBL8866060 | 0.87 | MMP1 (0.47) | TAAR1SLC6A2MAPK1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5382683-A | 2-aminopropanamide derivatives | FISONS CORPORATION (US) | 1995-01-17 | — | — | US | disclosed |
| EP-0326240-B1 | 2-Amino acetamide derivatives | FISONS CORP (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5093524-A | 2-(alkylamino)acetamide derivatives | FISONS CORPORATION (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0279937-B1 | 2-AMINOACETAMIDE DERIVATIVES | FISONS CORPORATION (US) | 1991-10-09 | — | — | EP | disclosed |
| US-5047541-A | 2-azacyclocarboxamide derivatives | FISONS CORPORATION (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0401253-A1 | 2-AMINO ACETAMIDE DERIVATIVES | FISONS CORPORATION (US) | 1990-12-12 | — | — | EP | disclosed |
| US-4871872-A | 2-[(2-aminoacetyl)amino]acetamide derivatives | FISONS CORPORATION (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0326240-A1 | 2-Amino acetamide derivatives | FISONS CORPORATION (US) | 1989-08-02 | — | — | EP | disclosed |
| WO-1989006646-A1 | 2-AMINO ACETAMIDE DERIVATIVES | FISONS CORPORATION (US) | 1989-07-27 | — | — | WO | disclosed |
| EP-0279937-A1 | 2-Aminoacetamide derivatives | FISONS CORPORATION (US) | 1988-08-31 | — | — | EP | disclosed |
| EP-0278089-A2 | 2-Azacyclocarboxamide derivatives | FISONS CORPORATION (a Massachusetts corporation) (US) | 1988-08-17 | — | — | EP | disclosed |