Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.45 |
| ▸ | BACE1 | P56817 | 6/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278858 | 0.85 | REN (0.57) | RENBACE1BACE2 | |
| SCHEMBL7269371 | 0.83 | REN (0.51) | REN | |
| SCHEMBL7269368 | 0.83 | REN (0.51) | REN | |
| SCHEMBL7269158 | 0.82 | REN (0.44) | RENBACE1PSMB5PTPRB | |
| SCHEMBL7269155 | 0.82 | REN (0.44) | RENBACE1PSMB5PTPRB | |
| SCHEMBL7269941 | 0.76 | CTSD (0.43) | RENPSMB5PTPRB | |
| SCHEMBL7275145 | 0.73 | REN (0.47) | RENBACE1BACE2PSMB5 | |
| SCHEMBL7275153 | 0.73 | REN (0.47) | RENBACE1BACE2PSMB5 | |
| SCHEMBL9725737 | 0.71 | REN (0.50) | RENPTPRB | |
| SCHEMBL7275371 | 0.70 | REN (0.50) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |