Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7262638 | 0.89 | SMN1; SMN2 (0.45) | SMN1; SMN2HPGDALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL7261507 | 0.82 | ALDH1A1 (0.52) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL5259886 | 0.78 | HPGD (0.40) | SMN1; SMN2HPGDALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL5258158 | 0.77 | GAA (0.40) | SMN1; SMN2HPGDALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL7267780 | 0.75 | HPGD (0.67) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| Hydrochloric Acid SCHEMBL8375906 | 0.73 | PDE10A (0.64) | PIK3CASMN1; SMN2ALDH1A1HIF1ACYP3A4 | |
| SCHEMBL7268690 | 0.71 | PDE1B (0.57) | SMN1; SMN2HPGDALDH1A1CYP3A4MAPK1 | |
| SCHEMBL7262055 | 0.70 | TGFBR1 (0.43) | SMN1; SMN2HPGDALDH1A1HIF1AUSP2 | |
| SCHEMBL7268671 | 0.70 | AURKA (0.45) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL7261986 | 0.69 | NPSR1 (0.47) | SMN1; SMN2HPGDALDH1A1HIF1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613772-B1 | Drugs such as 2-(p-chlorophenyl-4-(4-hydroxybutyl)amino-6,7,8 -trimethoxyquinazoline used for activation of guanylate cyclase and modulation of cyclic guanosine monophosphate | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-02 | — | — | US | disclosed |
| EP-1040101-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032460-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-01 | — | — | WO | disclosed |