Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359850 | 0.83 | MEN1 (0.53) | MEN1KMT2ANPSR1CTSSALDH1A1 | |
| SCHEMBL7322379 | 0.81 | FKBP1A (0.54) | MEN1KMT2ANPSR1FKBP1AALDH1A1 | |
| SCHEMBL7322372 | 0.81 | FKBP1A (0.54) | MEN1KMT2ANPSR1FKBP1AALDH1A1 | |
| SCHEMBL19390153 | 0.81 | MEN1 (0.61) | MEN1KMT2ANPSR1FKBP1AALDH1A1 | |
| SCHEMBL10059188 | 0.81 | MEN1 (0.61) | MEN1KMT2ANPSR1FKBP1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL5036983 | 0.80 | MEN1 (0.60) | MEN1KMT2ANPSR1FKBP1AALDH1A1 | |
| SCHEMBL8048833 | 0.78 | HSD17B10 (0.52) | CTSSALDH1A1HSD17B10CTSLCTSK | |
| SCHEMBL7355706 | 0.78 | HSD17B10 (0.52) | CTSSALDH1A1HSD17B10CTSLCTSK | |
| SCHEMBL27556472 | 0.77 | SLC15A1 (0.58) | CTSSALDH1A1HSD17B10CTSLCTSK | |
| SCHEMBL27556474 | 0.77 | SLC15A1 (0.58) | CTSSALDH1A1HSD17B10CTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |