Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB1 | P15086 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 2/20 | 0.30 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355730 | 0.81 | — | — | |
| SCHEMBL7275386 | 0.78 | CYP1A2 (0.38) | ALDH1A1ADAM17KDM4ECTSA | |
| SCHEMBL7268614 | 0.76 | L3MBTL1 (0.39) | ALDH1A1ADAM17CTSA | |
| SCHEMBL7268406 | 0.76 | L3MBTL1 (0.39) | ALDH1A1ADAM17CTSA | |
| SCHEMBL7275150 | 0.76 | L3MBTL1 (0.39) | ALDH1A1ADAM17CTSA | |
| SCHEMBL9095414 | 0.75 | L3MBTL1 (0.38) | CTSA | |
| SCHEMBL7267691 | 0.75 | L3MBTL1 (0.38) | CTSA | |
| SCHEMBL23521671 | 0.74 | ADAM17 (0.34) | ALDH1A1TSHRNOS1HSD17B10ADAM17 | |
| SCHEMBL30173737 | 0.74 | FFAR2 (0.37) | ALDH1A1ADAM17KDM4ELMNACTSA | |
| SCHEMBL1670553 | 0.73 | CA2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |
| EP-0376012-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |