Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.64 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MC4R | P32245 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PHGDH | O43175 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27655710 | 0.84 | CACNA1G (0.60) | KDM4ESIGMAR1LMNAHTTGAA | |
| SCHEMBL21797152 | 0.82 | KDM4E (0.68) | KDM4ESIGMAR1IGF1RLMNAHTT | |
| SCHEMBL1394539 | 0.82 | KDM4E (0.68) | KDM4ESIGMAR1IGF1RLMNAHTT | |
| SCHEMBL1394535 | 0.82 | KDM4E (0.68) | KDM4ESIGMAR1IGF1RLMNAHTT | |
| SCHEMBL1394677 | 0.82 | KDM4E (0.68) | KDM4ESIGMAR1IGF1RLMNAHTT | |
| SCHEMBL24672242 | 0.82 | KDM4E (0.68) | KDM4ESIGMAR1IGF1RLMNAHTT | |
| SCHEMBL27360918 | 0.82 | SIGMAR1 (0.64) | KDM4ESIGMAR1IGF1RLMNAGAA | |
| SCHEMBL4468044 | 0.81 | KDM4E (1.00) | KDM4ESIGMAR1IGF1RLMNAHTT | |
| SCHEMBL29201748 | 0.81 | KDM4E (0.66) | KDM4ESIGMAR1IGF1RLMNAHTT | |
| SCHEMBL7269243 | 0.81 | KDM4E (0.66) | KDM4ESIGMAR1IGF1RLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476848-A | Antihistamines | SANKYO COMPANY, LIMITED (JP) | 1995-12-19 | — | — | US | disclosed |
| US-5461051-A | Tetracyclic compounds having anti-allergic and anti-asthmatic activities and their use | SANKYO COMPANY, LIMITED (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5362725-A | Antiallergens, antiasthmatic | SANKYO COMPANY, LIMITED (JP) | 1994-11-08 | — | — | US | disclosed |
| EP-0505014-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1992-09-23 | — | — | EP | disclosed |
| EP-0421823-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1991-04-10 | — | — | EP | disclosed |