Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 2/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7264850 | 0.89 | TP53 (0.32) | MAPTACACARAB9AKDM4EEDNRA | |
| SCHEMBL7263814 | 0.86 | ACACA (0.33) | ACACAKDM4EEDNRASMN1; SMN2KMT2A | |
| SCHEMBL3701217 | 0.82 | ACACA (0.43) | MAPTACACARAB9AKDM4ELMNA | |
| SCHEMBL7122482 | 0.82 | DPP4 (0.35) | MAPTRAB9AKDM4ELMNAMAPK1 | |
| SCHEMBL14902890 | 0.82 | KDM4E (0.32) | MAPTKDM4ELMNAMAPK1SMN1; SMN2 | |
| SCHEMBL2400659 | 0.80 | KDM4E (0.38) | MAPTRAB9AKDM4ELMNAMAPK1 | |
| SCHEMBL7270823 | 0.79 | GPR84 (0.37) | RAB9AGPR84NPC1 | |
| SCHEMBL3926851 | 0.78 | DPP4 (0.36) | MAPTRAB9AKDM4ELMNAMAPK1 | |
| SCHEMBL7263818 | 0.74 | ACACA (0.38) | MAPTACACARAB9AKDM4ELMNA | |
| SCHEMBL13219242 | 0.74 | PDK2 (0.33) | TP53PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630597-B1 | Photochromic 6-aryl substituted 3H-naphtho(2, 1-b)pyran compounds, examples of which are naphthopyran compounds having a substituted aryl group at the number 6 carbon atom and certain substituents at the 3-position of the pyran ring | TRANSITIONS OPTICAL, INC. | 2003-10-07 | — | — | US | claimed |
| US-10758643-B2 | Mechanophoric medical product | AESCULAP AG (DE) | 2020-09-01 | — | — | US | disclosed |
| EP-3331581-B1 | MECHANOPHORIC MEDICAL PRODUKT | AESCULAP AG (DE) | 2020-07-08 | — | — | EP | disclosed |
| US-20190151502-A1 | Mechanophoric Medical Product | AESCULAP AG (DE) | 2019-05-23 | — | — | US | disclosed |
| EP-3331581-A1 | MECHANOPHORIC MEDICAL PRODUCT | Aesculap AG (DE) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017025408-A1 | MECHANOPHORIC MEDICAL PRODUCT | AESCULAP AG (DE) | 2017-02-16 | — | — | WO | disclosed |
| US-6630597-B1 | Photochromic 6-aryl substituted 3H-naphtho(2, 1-b)pyran compounds, examples of which are naphthopyran compounds having a substituted aryl group at the number 6 carbon atom and certain substituents at the 3-position of the pyran ring | TRANSITIONS OPTICAL, INC. | 2003-10-07 | — | — | US | disclosed |