Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 18/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 13/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7268682 | 1.00 | OPRD1 (0.45) | OPRD1OPRK1OPRM1CHRNB2CHRNB4 | |
| SCHEMBL7268687 | 0.90 | OPRD1 (0.53) | OPRD1OPRK1OPRM1CHRNB2CHRNB4 | |
| SCHEMBL7258711 | 0.90 | OPRD1 (0.53) | OPRD1OPRK1OPRM1CHRNB2CHRNB4 | |
| Citric Acid SCHEMBL7991902 | 0.84 | OPRD1 (0.41) | OPRD1OPRK1OPRM1 | |
| Citric Acid SCHEMBL7991900 | 0.84 | OPRD1 (0.41) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7262605 | 0.77 | OPRD1 (0.55) | OPRD1OPRK1OPRM1 | |
| Citric Acid SCHEMBL7977602 | 0.76 | MGLL (0.39) | — | |
| Citric Acid SCHEMBL7977599 | 0.76 | MGLL (0.39) | — | |
| Citric Acid SCHEMBL7989107 | 0.76 | MGLL (0.39) | — | |
| Citric Acid SCHEMBL7262615 | 0.73 | OPRM1 (0.46) | OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262104-B1 | SELECTIVE DELTA OPIOID AGONISTS AND ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-07-17 | — | — | US | claimed |
| EP-0873330-A1 | DIARYLALKENYLAMINE DERIVATIVES | Smithkline Beecham S.p.A. (IT) | 1998-10-28 | — | — | EP | claimed |
| WO-1997010230-A1 | DIARYLALKENYLAMINE DERIVATIVES | SMITHKLINE BEECHAM S.P.A. (IT) | 1997-03-20 | — | — | WO | claimed |
| EP-0873330-B1 | DIARYLALKENYLAMINE DERIVATIVES | GLAXOSMITHKLINE SPA (IT) | 2003-05-14 | — | — | EP | disclosed |
| US-6262104-B1 | SELECTIVE DELTA OPIOID AGONISTS AND ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-07-17 | — | — | US | disclosed |
| EP-0873330-A1 | DIARYLALKENYLAMINE DERIVATIVES | Smithkline Beecham S.p.A. (IT) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997010230-A1 | DIARYLALKENYLAMINE DERIVATIVES | SMITHKLINE BEECHAM S.P.A. (IT) | 1997-03-20 | — | — | WO | disclosed |