Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 16/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7977602 | 1.00 | MGLL (0.39) | MGLLHPGDNPC1TP53RAB9A | |
| Citric Acid SCHEMBL7977599 | 1.00 | MGLL (0.39) | MGLLHPGDNPC1TP53RAB9A | |
| SCHEMBL7263161 | 0.89 | MGLL (0.47) | MGLLHPGDTP53ALDH1A1HTT | |
| SCHEMBL7263159 | 0.89 | MGLL (0.47) | MGLLHPGDTP53ALDH1A1HTT | |
| SCHEMBL7263163 | 0.89 | MGLL (0.47) | MGLLHPGDTP53ALDH1A1HTT | |
| Citric Acid SCHEMBL7991902 | 0.82 | OPRD1 (0.41) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| Citric Acid SCHEMBL7991900 | 0.82 | OPRD1 (0.41) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| Citric Acid SCHEMBL7270037 | 0.76 | OPRD1 (0.45) | — | |
| Citric Acid SCHEMBL7268682 | 0.76 | OPRD1 (0.45) | — | |
| SCHEMBL7268696 | 0.76 | HPGD (0.52) | MGLLHPGDNPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262104-B1 | SELECTIVE DELTA OPIOID AGONISTS AND ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-07-17 | — | — | US | claimed |