Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276909 | 0.98 | ALDH1A1 (0.40) | ALDH1A1SOAT1MEN1KMT2ATSHR | |
| SCHEMBL11592228 | 0.81 | ALDH1A1 (0.40) | ALDH1A1SOAT1MEN1KMT2AKDM4E | |
| SCHEMBL3816283 | 0.78 | ALDH1A1 (0.33) | ALDH1A1TSHRKDM4EMAPTALOX12 | |
| SCHEMBL10929994 | 0.77 | ALDH1A1 (0.38) | ALDH1A1BACE1 | |
| SCHEMBL7058356 | 0.75 | ALDH1A1 (0.50) | ALDH1A1SOAT1MEN1KMT2AKDM4E | |
| SCHEMBL10033536 | 0.75 | KDM4E (0.33) | ALDH1A1DPP4KDM4EBACE1 | |
| SCHEMBL9236338 | 0.74 | BRD4 (0.40) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL9843658 | 0.74 | ALDH1A1 (0.38) | ALDH1A1DPP4MAPTLMNABACE1 | |
| SCHEMBL11096615 | 0.73 | BACE1 (0.31) | DPP4KDM4EBACE1 | |
| SCHEMBL8308690 | 0.73 | ALDH1A1 (0.48) | ALDH1A1SOAT1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528762-B1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| EP-0528762-A1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA-GEIGY AG (CH) | 1993-02-24 | — | — | EP | disclosed |