Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TXNRD1 | Q16881 | 6/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | LOX | P28300 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28888991 | 0.83 | LMNA (0.44) | SMN1; SMN2LMNATXNRD1MTNR1AMTNR1B | |
| SCHEMBL27455546 | 0.83 | LMNA (0.44) | SMN1; SMN2LMNATXNRD1MTNR1AMTNR1B | |
| Water SCHEMBL27347655 | 0.81 | LMNA (0.43) | SMN1; SMN2LMNATXNRD1MTNR1AMTNR1B | |
| SCHEMBL2411422 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAPARP1ALDH1A1TP53 | |
| SCHEMBL29242561 | 0.81 | LMNA (0.43) | SMN1; SMN2LMNATXNRD1MTNR1AMTNR1B | |
| SCHEMBL7696606 | 0.80 | ALDH1A1 (0.43) | SMN1; SMN2LMNATXNRD1PARP1KMT2A | |
| SCHEMBL32665306 | 0.80 | LMNA (0.42) | SMN1; SMN2LMNAPARP1ALDH1A1TP53 | |
| SCHEMBL28858783 | 0.80 | LMNA (0.42) | SMN1; SMN2LMNAPARP1ALDH1A1TP53 | |
| SCHEMBL24725108 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAPARP1KMT2AKDM4E | |
| SCHEMBL27836920 | 0.79 | KMT2A (0.41) | SMN1; SMN2LMNATXNRD1PARP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301491-A1 | PROCESS FOR THE PREPARATION OF 4,6-DIMETHOXY-2-(METHYLSULFONYL)-1,3-PYRIMIDINE | Syngenta Participations AG (CH) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002008207-A1 | PROCESS FOR THE PREPARATION OF 4,6-DIMETHOXY-2-(METHYLSULFONYL)-1,3-PYRIMIDINE | SYNGENTA PARTICIPATIONS AG (CH) | 2002-01-31 | — | — | WO | disclosed |