Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.34 |
| ▸ | HPGD | P15428 | 6/20 | 0.34 |
| ▸ | SDHB | P21912 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 5/20 | 0.34 |
| ▸ | STAT3 | P40763 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | STAT1 | P42224 | 2/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28858783 | 0.85 | LMNA (0.42) | SMN1; SMN2LMNANPSR1TP53HTT | |
| SCHEMBL18382 | 0.81 | NR1H2 (0.41) | SMN1; SMN2LMNANPSR1HPGDSDHB | |
| SCHEMBL7270618 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNANPSR1HPGDTP53 | |
| SCHEMBL8637660 | 0.78 | LMNA (0.37) | SMN1; SMN2LMNAPTGS2 | |
| SCHEMBL32665306 | 0.78 | LMNA (0.42) | SMN1; SMN2LMNANPSR1TP53HTT | |
| SCHEMBL27836920 | 0.77 | KMT2A (0.41) | SMN1; SMN2LMNANPSR1TP53KDM4E | |
| SCHEMBL2415488 | 0.76 | KDM4E (0.49) | SMN1; SMN2LMNANPSR1HPGDSDHB | |
| SCHEMBL2411422 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNANPSR1HPGDTP53 | |
| SCHEMBL7696606 | 0.75 | ALDH1A1 (0.43) | SMN1; SMN2LMNANPSR1TP53HTT | |
| SCHEMBL7984890 | 0.74 | NUDT1 (0.41) | SMN1; SMN2LMNANPSR1TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117677399-A | Effective ASGPR binding compounds for the degradation of immunoglobulins and other proteins | 阿维拉治疗公司 | 2024-03-08 | — | — | CN | disclosed |
| WO-2022235699-A2 | POTENT ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |