Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270056 | 0.89 | NPSR1 (0.46) | MEN1KMT2ARAB9AALDH1A1CYP1A2 | |
| SCHEMBL10640910 | 0.85 | ALDH1A1 (0.49) | MEN1KMT2ABCHEALDH1A1L3MBTL1 | |
| SCHEMBL7263517 | 0.84 | ADRB2 (0.53) | MEN1KMT2ARAB9AALDH1A1L3MBTL1 | |
| SCHEMBL7287608 | 0.84 | CYP1A2 (0.44) | KMT2AALDH1A1CYP1A2CYP2D6PKM | |
| SCHEMBL10831891 | 0.83 | CYP1A2 (0.41) | MEN1KMT2ARAB9AALDH1A1CYP1A2 | |
| SCHEMBL7264080 | 0.82 | CYP1A2 (0.45) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7271252 | 0.82 | GPR139 (0.51) | MEN1KMT2ARAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL10641538 | 0.80 | GPR139 (0.44) | MEN1KMT2ARAB9AALDH1A1L3MBTL1 | |
| SCHEMBL10635569 | 0.80 | SMN1; SMN2 (0.46) | MEN1KMT2ARAB9AALDH1A1L3MBTL1 | |
| SCHEMBL10911592 | 0.78 | CES2 (0.45) | RAB9AALDH1A1L3MBTL1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067770-B1 | TREATMENT OF MIGRAINE WITH TROPYL BENZOATE DERIVATIVES | MERRELL DOW FRANCE ET CIE (FR) | 1992-01-15 | — | — | EP | claimed |
| US-4563465-A | ANTISEROTONINE AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-01-07 | — | — | US | claimed |
| EP-0067770-A2 | Treatment of migraine with tropyl benzoate derivatives | MERRELL DOW FRANCE ET CIE (FR) | 1982-12-22 | — | — | EP | claimed |
| EP-0067770-B1 | TREATMENT OF MIGRAINE WITH TROPYL BENZOATE DERIVATIVES | MERRELL DOW FRANCE ET CIE (FR) | 1992-01-15 | — | — | EP | disclosed |
| EP-0067770-A2 | Treatment of migraine with tropyl benzoate derivatives | MERRELL DOW FRANCE ET CIE (FR) | 1982-12-22 | — | — | EP | disclosed |