Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272900 | 0.92 | LMNA (0.45) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7280554 | 0.90 | LMNA (0.43) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7273349 | 0.89 | LMNA (0.43) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7278535 | 0.87 | CACNA1F (0.44) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7278443 | 0.85 | CACNA1F (0.46) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7272658 | 0.82 | ALDH1A1 (0.48) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7282275 | 0.81 | CA1 (0.49) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7272539 | 0.80 | CACNA1F (0.43) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7278639 | 0.79 | TSHR (0.52) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7282356 | 0.79 | LMNA (0.54) | LMNAALDH1A1MAPTNPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |