Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PTAFR | P25105 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282275 | 0.89 | CA1 (0.49) | TSHRCYP2C9CYP3A4KDM4ETBXA2R | |
| SCHEMBL4261000 | 0.86 | MAPT (0.56) | TSHRCYP2C9CYP3A4KDM4ETBXA2R | |
| SCHEMBL10575549 | 0.86 | TSHR (0.48) | TSHRPOLBPTAFRCYP2C9CYP3A4 | |
| SCHEMBL7282356 | 0.85 | LMNA (0.54) | TSHRPTAFRCYP2C9CYP3A4KDM4E | |
| SCHEMBL7281990 | 0.85 | ADORA3 (0.58) | TSHRCYP2C9CYP3A4KDM4ECYP2C19 | |
| SCHEMBL7282331 | 0.84 | ACHE (0.56) | TSHRCYP2C9CYP3A4KDM4EADRA1A | |
| SCHEMBL7272658 | 0.82 | ALDH1A1 (0.48) | TSHRPTAFRCYP2C9CYP3A4KDM4E | |
| SCHEMBL3017208 | 0.81 | CYP2C9 (0.73) | TSHRPOLBPTAFRCYP2C9CYP3A4 | |
| SCHEMBL7272340 | 0.79 | LMNA (0.45) | TSHRCYP3A4ALDH1A1HSD17B10CACNA1C | |
| SCHEMBL7273090 | 0.78 | ACHE (0.54) | TSHRPOLBCYP2C9CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |