Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272340 | 0.89 | LMNA (0.45) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7272900 | 0.88 | LMNA (0.45) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7271095 | 0.88 | CACNA1C (0.42) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7280554 | 0.87 | LMNA (0.43) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7271027 | 0.83 | ALDH1A1 (0.46) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7272890 | 0.81 | LMNA (0.51) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7271051 | 0.78 | ACHE (0.53) | LMNAALDH1A1MAPTKMT2ACACNA1F | |
| SCHEMBL7272968 | 0.78 | CACNA1C (0.50) | LMNAALDH1A1MAPTKMT2ACACNA1F | |
| SCHEMBL7272539 | 0.77 | CACNA1F (0.43) | LMNAALDH1A1MAPTNPSR1KMT2A | |
| SCHEMBL7278535 | 0.77 | CACNA1F (0.44) | LMNAALDH1A1MAPTNPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |