Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | NAAA | Q02083 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | CTSG | P08311 | 1/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18689914 | 0.85 | LMNA (0.69) | LMNAPOLBNAAAGAASMN1; SMN2 | |
| SCHEMBL237683 | 0.83 | GAA (0.63) | LMNAPOLBNAAAGAASMN1; SMN2 | |
| SCHEMBL3192014 | 0.83 | LMNA (0.77) | LMNAPOLBNAAAGAASMN1; SMN2 | |
| SCHEMBL8851577 | 0.82 | LMNA (0.66) | LMNAPOLBNAAAGAASMN1; SMN2 | |
| SCHEMBL8851817 | 0.81 | DRD2 (0.68) | LMNAPOLBNAAAGAASMN1; SMN2 | |
| SCHEMBL14067433 | 0.80 | LMNA (0.62) | LMNAPOLBNAAAGAASMN1; SMN2 | |
| SCHEMBL10784098 | 0.80 | GAA (0.59) | LMNAPOLBNAAAGAASMN1; SMN2 | |
| SCHEMBL11251484 | 0.79 | LMNA (0.61) | LMNAPOLBNAAAGAASMN1; SMN2 | |
| SCHEMBL3075535 | 0.79 | LMNA (0.61) | LMNAPOLBNAAAGAASMN1; SMN2 | |
| SCHEMBL1754794 | 0.78 | LMNA (0.70) | LMNAPOLBNAAAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049605-B1 | SUBSTITUTED ACYL DERIVATIVES OF 1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACIDS, SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR SALTS, AND THE PRODUCTION OF THE SAME | WARNER-LAMBERT COMPANY (US) | 1987-03-18 | — | — | EP | disclosed |
| EP-0037231-B1 | SUBSTITUTED ACYL DERIVATIVES OF OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACIDS | WARNER-LAMBERT COMPANY (US) | 1987-01-28 | — | — | EP | disclosed |
| US-4532342-A | N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids | WARNER-LAMBERT COMPANY (US) | 1985-07-30 | — | — | US | disclosed |
| US-4503043-A | HYPOTENSIVES | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0058567-B1 | SUBSTITUTED ACYL DERIVATIVES OF OCTAHYDRO-1H-ISOINDOLE-1-CARBOXYLIC ACIDS AND ESTERS | WARNER-LAMBERT COMPANY (US) | 1984-07-25 | — | — | EP | disclosed |
| US-4425355-A | HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1984-01-10 | — | — | US | disclosed |
| EP-0096157-A2 | Substituted acyl derivatives of 1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid | WARNER-LAMBERT COMPANY (US) | 1983-12-21 | — | — | EP | disclosed |
| EP-0088342-A1 | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids | WARNER-LAMBERT COMPANY (US) | 1983-09-14 | — | — | EP | disclosed |
| US-4350704-A | HYPOTENSIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1982-09-21 | — | — | US | disclosed |
| US-4344949-A | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids | WARNER-LAMBERT COMPANY (US) | 1982-08-17 | — | — | US | disclosed |
| EP-0049605-A1 | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same | WARNER-LAMBERT COMPANY (US) | 1982-04-14 | — | — | EP | disclosed |
| EP-0037231-A2 | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids | WARNER-LAMBERT COMPANY (US) | 1981-10-07 | — | — | EP | disclosed |