Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.45 |
| ▸ | HTR3B | O95264 | 5/20 | 0.45 |
| ▸ | HTR3A | P46098 | 5/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267112 | 1.00 | HTR3E (0.45) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL7324702 | 0.83 | KDM4E (0.37) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7302348 | 0.78 | KDM4E (0.42) | MEN1KMT2AKDM4ENOTUMCHRNA7 | |
| SCHEMBL9871559 | 0.76 | HTR3A (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9472450 | 0.76 | HTR3A (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7265701 | 0.76 | HTR3A (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6139012 | 0.76 | HTR3A (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7301445 | 0.75 | KDM4E (0.45) | CYP2D6MEN1KMT2AKDM4ENOTUM | |
| Hydrochloric Acid SCHEMBL7301304 | 0.74 | KDM4E (0.44) | CYP2D6MEN1KMT2AKDM4ENOTUM | |
| SCHEMBL7973793 | 0.71 | HTR3E (0.40) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221878-B1 | ANTAGONISTS OF 5-HYDROXYTRYPTAMINE (5-HT) AT 5-HT3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2001-04-24 | — | — | US | claimed |
| US-5411968-A | 5-hydroxytryptamine antagonists | GLAXO GROUP LIMITED (GB) | 1995-05-02 | — | — | US | claimed |
| EP-0278173-B1 | Use of heterocyclic derivatives in the treatment of depressions | GLAXO GROUP LTD (GB) | 1993-11-03 | — | — | EP | claimed |
| EP-0229444-A2 | Medicaments for the treatment of anxiety | GLAXO GROUP LIMITED (GB) | 1987-07-22 | — | — | EP | claimed |
| EP-0229444-B1 | Medicaments for the treatment of anxiety | GLAXO GROUP LTD (GB) | 1997-09-17 | — | — | EP | disclosed |
| US-5198447-A | Aid for withdrawal from drugs, alcohol, cigarettes | GLAXO GROUP LIMITED (GB) | 1993-03-30 | — | — | US | disclosed |
| US-4883803-A | TROPANYL-INDOLE ESTERS | GLAXO GROUP LIMITED (GB) | 1989-11-28 | — | — | US | disclosed |