Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | DRD5 | P21918 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7301304 | 0.98 | KDM4E (0.44) | KDM4EMEN1CYP2D6KMT2APLAT | |
| SCHEMBL5546531 | 0.81 | HTR2C (0.48) | MEN1CYP2D6KMT2APLATHTR2C | |
| SCHEMBL7302348 | 0.79 | KDM4E (0.42) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL27536215 | 0.76 | ACMSD (0.46) | KDM4EMAPTNOTUMLMNA | |
| SCHEMBL27544733 | 0.75 | HTR2C (0.40) | MEN1CYP2D6KMT2APLATHTR2C | |
| SCHEMBL27516462 | 0.75 | ACMSD (0.47) | KDM4EKMT2ADHODHMAPTNOTUM | |
| SCHEMBL7273067 | 0.75 | HTR3E (0.45) | KDM4EMEN1CYP2D6KMT2AMAPT | |
| SCHEMBL7267112 | 0.75 | HTR3E (0.45) | KDM4EMEN1CYP2D6KMT2AMAPT | |
| SCHEMBL27866187 | 0.73 | MAPT (0.45) | KDM4EDHODHALDH1A1MAPTNOTUM | |
| SCHEMBL13646142 | 0.72 | ACMSD (0.50) | DHODHHTR2CNOTUMP2RY14ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252570-A | Amidino and guanidino derivatives | B.I. ITALIA (IT) | 1993-10-12 | — | — | US | disclosed |
| US-5047410-A | Indolyl derivatives and their use as 5-HT3, receptor antagonists | ISTITUTO DE ANGELI S.P.A. (IT) | 1991-09-10 | — | — | US | disclosed |
| EP-0351385-A2 | New amidino and guanidino derivatives | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1990-01-17 | — | — | EP | disclosed |