Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 4/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283895 | 0.91 | CA12 (0.41) | CA12CA1CA2CA9HDAC3 | |
| SCHEMBL7273844 | 0.89 | SIGMAR1 (0.51) | CA1CA2HDAC3HDAC1HDAC8 | |
| SCHEMBL7275131 | 0.89 | SIGMAR1 (0.51) | CA1CA2HDAC3HDAC1HDAC8 | |
| SCHEMBL7274594 | 0.89 | SIGMAR1 (0.51) | CA1CA2HDAC3HDAC1HDAC8 | |
| SCHEMBL7276194 | 0.88 | SIGMAR1 (0.47) | CA1CA2HDAC3HDAC1HDAC8 | |
| SCHEMBL7274726 | 0.88 | SIGMAR1 (0.51) | CA1CA2HDAC3HDAC1HDAC8 | |
| SCHEMBL7273855 | 0.86 | HDAC1 (0.39) | HDAC3HDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL7282422 | 0.86 | CYP3A4 (0.47) | HDAC3HDAC1HDAC8HDAC6CACNA1G | |
| SCHEMBL7283478 | 0.85 | SIGMAR1 (0.54) | CA1CA2HDAC3HDAC1HDAC8 | |
| SCHEMBL8884029 | 0.85 | HDAC1 (0.42) | HDAC3HDAC1HDAC8HDAC6HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |