Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5167168 | 0.78 | ALDH1A1 (0.31) | CYP1A2CYP2C19HTTHIF1ATDP1 | |
| SCHEMBL9099235 | 0.74 | KDM4E (0.41) | GABRA1GABRB2KDM4EGAAMAPT | |
| SCHEMBL31718392 | 0.74 | SIGMAR1 (0.37) | CYP1A2CYP2C19HTTHIF1ATDP1 | |
| SCHEMBL9513523 | 0.72 | ALDH1A1 (0.33) | CYP1A2CYP2C19HTTTDP1L3MBTL1 | |
| SCHEMBL7273191 | 0.71 | TDP1 (0.38) | CYP1A2CYP2C19HTTHIF1ATDP1 | |
| SCHEMBL11487423 | 0.70 | ALDH1A1 (0.40) | TDP1L3MBTL1KDM4EMAPT | |
| SCHEMBL4976591 | 0.70 | ALDH1A1 (0.34) | CYP1A2CYP2C19HTTHIF1ATDP1 | |
| SCHEMBL2495979 | 0.70 | MGLL (0.41) | HTTL3MBTL1GABRA1GABRB2KDM4E | |
| SCHEMBL14511099 | 0.69 | SIGMAR1 (0.33) | CYP1A2CYP2C19HTTHIF1ATDP1 | |
| SCHEMBL26418632 | 0.69 | ALDH1A1 (0.41) | CYP1A2CYP2C19HTTHIF1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470514-B1 | Carbostyril derivatives and pharmaceutical composition containing the same | OTSUKA PHARMA CO LTD (JP) | 1997-02-19 | — | — | EP | disclosed |
| US-5300513-A | Vasopressin antagonists; vasodilators, hypotensive agents, water diuretics, and platelet agglutination inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| EP-0470514-A1 | Carbostyril derivatives and pharmaceutical composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-02-12 | — | — | EP | disclosed |