Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280841 | 0.79 | LMNA (0.48) | TDP1HTTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL3743837 | 0.76 | TDP1 (0.35) | TDP1HTTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL9099245 | 0.74 | KDM4E (0.41) | TDP1HTTL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL31718392 | 0.74 | SIGMAR1 (0.37) | TDP1HTTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL2489167 | 0.73 | KDM4E (0.45) | TDP1HTTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL7273186 | 0.71 | CYP1A2 (0.34) | TDP1HTTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL4976591 | 0.70 | ALDH1A1 (0.34) | TDP1HTTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL30450577 | 0.70 | CHEK1 (0.42) | TDP1HTTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL5637004 | 0.70 | CHEK1 (0.42) | TDP1HTTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL2495979 | 0.70 | MGLL (0.41) | HTTL3MBTL1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470514-B1 | Carbostyril derivatives and pharmaceutical composition containing the same | OTSUKA PHARMA CO LTD (JP) | 1997-02-19 | — | — | EP | disclosed |
| US-5300513-A | Vasopressin antagonists; vasodilators, hypotensive agents, water diuretics, and platelet agglutination inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| EP-0470514-A1 | Carbostyril derivatives and pharmaceutical composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-02-12 | — | — | EP | disclosed |