Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11404773 | 0.86 | DRD4 (0.54) | GAAMEN1KMT2ATDP1ATM | |
| SCHEMBL3345622 | 0.85 | TDP1 (0.59) | TDP1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7629438 | 0.83 | LMNA (0.60) | MEN1KMT2ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9212249 | 0.80 | LMNA (0.65) | GAATAAR1MEN1KMT2ATDP1 | |
| Hydrochloric Acid SCHEMBL10658571 | 0.79 | GAA (0.49) | GAATAAR1MEN1KMT2ATDP1 | |
| SCHEMBL7382600 | 0.78 | ALDH1A1 (0.51) | KMT2ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9261769 | 0.77 | ALDH1A1 (0.66) | GAAMEN1KMT2ASIGMAR1ALDH1A1 | |
| SCHEMBL28318418 | 0.77 | ALDH1A1 (0.50) | KMT2ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12088285 | 0.76 | MAPT (0.42) | GAAMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL11307950 | 0.76 | THRB (0.56) | GAATAAR1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |