Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273321 | 1.00 | HRH4 (0.34) | HRH4GPR139KCNH2HRH3MEN1 | |
| SCHEMBL7267651 | 0.83 | HTR4 (0.31) | ADORA2A | |
| SCHEMBL7267645 | 0.83 | HTR4 (0.31) | ADORA2A | |
| SCHEMBL7266786 | 0.79 | GPR139 (0.39) | GPR139MEN1KMT2ALMNA | |
| SCHEMBL17950446 | 0.68 | GPR139 (0.44) | HRH4GPR139MEN1KMT2AHTR3A | |
| SCHEMBL21751104 | 0.66 | CRBN (0.54) | — | |
| SCHEMBL12963517 | 0.66 | ALDH1A1 (0.64) | GPR139MEN1KMT2AL3MBTL1 | |
| SCHEMBL8350769 | 0.64 | GPR139 (0.54) | GPR139MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL6258585 | 0.63 | KDM4E (0.50) | GPR139MEN1KMT2AKDM4ELMNA | |
| SCHEMBL7266973 | 0.61 | ALDH1A1 (0.49) | MEN1KMT2AHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315390-B1 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1994-07-20 | — | — | EP | claimed |
| US-4959367-A | ANALGESICS, TRANQUILIZERS, GASTROINTESTINAL, CNS | BEECHAM GROUP P.L.C. (GB) | 1990-09-25 | — | — | US | claimed |
| EP-0315390-A2 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1989-05-10 | — | — | EP | claimed |
| EP-0315390-B1 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1994-07-20 | — | — | EP | disclosed |
| US-4959367-A | ANALGESICS, TRANQUILIZERS, GASTROINTESTINAL, CNS | BEECHAM GROUP P.L.C. (GB) | 1990-09-25 | — | — | US | disclosed |
| EP-0315390-A2 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1989-05-10 | — | — | EP | disclosed |