Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266786 | 0.82 | GPR139 (0.39) | CYP2C19MEN1KMT2A | |
| SCHEMBL7276249 | 0.75 | HTR4 (0.39) | CYP1A2GAAALOX15HTR3A | |
| SCHEMBL7267551 | 0.70 | HTR4 (0.35) | HTR3AMAPK1 | |
| SCHEMBL904817 | 0.70 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19MEN1 | |
| SCHEMBL7267544 | 0.68 | PGK1 (0.33) | SMN1; SMN2MEN1KMT2AHTR3A | |
| SCHEMBL21751113 | 0.68 | CRBN (0.59) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL15878936 | 0.66 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19MEN1 | |
| SCHEMBL13831514 | 0.66 | SMN1; SMN2 (1.00) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19MEN1 | |
| SCHEMBL7436441 | 0.66 | HTR3A (0.50) | HTR3A | |
| SCHEMBL14539588 | 0.65 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315390-B1 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1994-07-20 | — | — | EP | claimed |
| US-4959367-A | ANALGESICS, TRANQUILIZERS, GASTROINTESTINAL, CNS | BEECHAM GROUP P.L.C. (GB) | 1990-09-25 | — | — | US | claimed |
| EP-0315390-A2 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1989-05-10 | — | — | EP | claimed |
| EP-0315390-B1 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1994-07-20 | — | — | EP | disclosed |
| US-4959367-A | ANALGESICS, TRANQUILIZERS, GASTROINTESTINAL, CNS | BEECHAM GROUP P.L.C. (GB) | 1990-09-25 | — | — | US | disclosed |
| EP-0315390-A2 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1989-05-10 | — | — | EP | disclosed |