Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273339 | 1.00 | CASP1 (0.40) | CASP1PPARASLC15A1MC4RPSMB5 | |
| SCHEMBL7274947 | 0.88 | SLC15A1 (0.44) | PPARASLC15A1NPC1HRH4CYP3A4 | |
| SCHEMBL7274942 | 0.88 | SLC15A1 (0.44) | PPARASLC15A1NPC1HRH4CYP3A4 | |
| SCHEMBL2299084 | 0.87 | IL6ST (0.47) | CASP1SLC15A1MC4RPSMB5KDM4E | |
| SCHEMBL2299086 | 0.87 | IL6ST (0.47) | CASP1SLC15A1MC4RPSMB5KDM4E | |
| SCHEMBL2299083 | 0.87 | IL6ST (0.47) | CASP1SLC15A1MC4RPSMB5KDM4E | |
| SCHEMBL7312186 | 0.85 | PPARA (0.42) | PPARAMC4RKMT2AHRH4TACR1 | |
| SCHEMBL7296207 | 0.84 | PPARA (0.41) | PPARAPSMB5KDM4EKMT2ATACR1 | |
| SCHEMBL7288366 | 0.84 | PPARA (0.38) | PPARAKDM4EKMT2AHRH4TACR1 | |
| SCHEMBL7291357 | 0.83 | PPARA (0.38) | PPARAKDM4EKMT2AHRH4TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-B1 | New renin-inhibitory oligopeptides, their preparaton and their use | SANKYO CO (JP) | 1994-02-16 | — | — | EP | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |