Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 10/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287579 | 0.85 | PPARA (0.45) | PPARAPSMB8MEN1KMT2ATACR1 | |
| SCHEMBL7312186 | 0.85 | PPARA (0.42) | PPARAPSMB8KMT2ATACR1 | |
| SCHEMBL7288366 | 0.84 | PPARA (0.38) | PPARAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL7273333 | 0.84 | CASP1 (0.40) | PPARAPSMB5HTR2ACYP3A4KDM4E | |
| SCHEMBL7273339 | 0.84 | CASP1 (0.40) | PPARAPSMB5HTR2ACYP3A4KDM4E | |
| SCHEMBL7287672 | 0.84 | PPARA (0.39) | PPARAKDM4EMEN1KMT2ACHRM1 | |
| SCHEMBL7291357 | 0.83 | PPARA (0.38) | PPARACYP3A4KDM4EMEN1KMT2A | |
| SCHEMBL7292195 | 0.83 | KMT2A (0.39) | PPARAMEN1KMT2ANAAAPOLB | |
| SCHEMBL7273664 | 0.83 | DPP4 (0.40) | PPARAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL7273674 | 0.83 | DPP4 (0.40) | PPARAKDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |