Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | CLPP | Q16740 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.37 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.37 |
| ▸ | TCF7 | P36402 | 2/20 | 0.37 |
| ▸ | BCL9 | O00512 | 1/20 | 0.37 |
| ▸ | TCF4 | P15884 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290361 | 0.92 | MEN1 (0.46) | PPARASIGMAR1HRH4PSMB8KMT2A | |
| SCHEMBL7287579 | 0.91 | PPARA (0.45) | PPARACLPPIDH1PPARGHRH4 | |
| SCHEMBL7288366 | 0.85 | PPARA (0.38) | PPARACLPPSIGMAR1CTNNB1HRH4 | |
| SCHEMBL7273339 | 0.85 | CASP1 (0.40) | PPARACTNNB1MC4RHRH4TACR1 | |
| SCHEMBL7273333 | 0.85 | CASP1 (0.40) | PPARACTNNB1MC4RHRH4TACR1 | |
| SCHEMBL7296207 | 0.85 | PPARA (0.41) | PPARATACR1PSMB8KMT2A | |
| SCHEMBL7291357 | 0.84 | PPARA (0.38) | PPARAHRH4TACR1KMT2A | |
| SCHEMBL7273674 | 0.83 | DPP4 (0.40) | PPARAKMT2A | |
| SCHEMBL7273664 | 0.83 | DPP4 (0.40) | PPARAKMT2A | |
| SCHEMBL7288445 | 0.83 | PPARA (0.37) | PPARACLPPSIGMAR1CTNNB1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |