Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 9/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.52 |
| ▸ | HTR3B | O95264 | 5/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.52 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7435410 | 0.99 | HTR3A (0.55) | HTR3ATMEM97SIGMAR1HTR4ALDH1A1 | |
| SCHEMBL7267718 | 0.86 | ALDH1A1 (0.55) | HTR3ATMEM97SIGMAR1HTR4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7443261 | 0.85 | ALDH1A1 (0.54) | HTR3ATMEM97SIGMAR1HTR4ALDH1A1 | |
| SCHEMBL9602256 | 0.82 | ALDH1A1 (0.51) | HTR3ATMEM97SIGMAR1HTR4ALDH1A1 | |
| SCHEMBL7266776 | 0.76 | HTR3A (0.55) | HTR3ATMEM97SIGMAR1HTR4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7429564 | 0.75 | HTR3A (0.54) | HTR3ATMEM97SIGMAR1HTR4ALDH1A1 | |
| SCHEMBL9478363 | 0.73 | DRD2 (0.42) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL1041383 | 0.72 | HTR4 (1.00) | HTR3ATMEM97SIGMAR1HTR4HTR3E | |
| SCHEMBL6669870 | 0.72 | HTR4 (1.00) | HTR3ATMEM97SIGMAR1HTR4HTR3E | |
| SCHEMBL7343018 | 0.71 | HTR3A (0.85) | HTR3ATMEM97SIGMAR1HTR4HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278173-B1 | Use of heterocyclic derivatives in the treatment of depressions | GLAXO GROUP LTD (GB) | 1993-11-03 | — | — | EP | claimed |
| EP-0247266-B1 | INDOLE DERIVATIVES HAVING AN AZABICYCLIC SIDE CHAIN, PROCESS FOR THEIR PREPARATION, INTERMEDIATES, AND PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1993-03-10 | — | — | EP | claimed |
| EP-0247266-A1 | Indole derivatives having an azabicyclic side chain, process for their preparation, intermediates, and pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1987-12-02 | — | — | EP | claimed |
| EP-0278173-B1 | Use of heterocyclic derivatives in the treatment of depressions | GLAXO GROUP LTD (GB) | 1993-11-03 | — | — | EP | disclosed |