Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 5/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7285771 | 0.89 | ALDH1A1 (0.33) | ALDH1A1PDE2APPARDPPARA | |
| SCHEMBL7274092 | 0.89 | ALDH1A1 (0.53) | ALDH1A1PDE2AMAPT | |
| SCHEMBL7273900 | 0.81 | ALDH1A1 (0.33) | ALDH1A1PDE2APPARDPPARA | |
| SCHEMBL7285392 | 0.79 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL5114514 | 0.70 | MME (0.45) | ALDH1A1 | |
| SCHEMBL5110447 | 0.70 | MME (0.45) | ALDH1A1 | |
| SCHEMBL8731461 | 0.69 | THRB (0.51) | ALDH1A1PPARGMAPT | |
| SCHEMBL5114432 | 0.67 | MDM4 (0.42) | ALDH1A1MAPT | |
| SCHEMBL5549364 | 0.67 | MDM4 (0.42) | ALDH1A1MAPT | |
| SCHEMBL8730077 | 0.67 | BACE1 (0.43) | EPHX2PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061798-A | Intermediates in the formation of synthetic hormones, mimic effects of thyroid hormones; little or no effect on the heart | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-10-29 | — | — | US | disclosed |
| EP-0188351-B1 | CHEMICAL COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-03-13 | — | — | EP | disclosed |
| US-4910305-A | Containing a protected 4-hydroxyphenyl | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-03-20 | — | — | US | disclosed |
| US-4826876-A | WITHOUT EFFECT ON HEART | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-05-02 | — | — | US | disclosed |
| US-4766121-A | NOT AFFECTING THE HEART | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1988-08-23 | — | — | US | disclosed |
| EP-0188351-A2 | Chemical compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |