Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 5/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274092 | 0.90 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2ALMNAHTT | |
| SCHEMBL7285771 | 0.90 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7273900 | 0.89 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7274397 | 0.79 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL7273661 | 0.75 | FOLH1 (0.37) | — | |
| SCHEMBL7276676 | 0.72 | ALDH1A1 (0.46) | ALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL10414279 | 0.71 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7276444 | 0.70 | MAPT (0.41) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7281994 | 0.69 | ALDH1A1 (0.41) | ALDH1A1CYP1A2CYP3A4CYP2C19LMNA | |
| SCHEMBL7989753 | 0.68 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061798-A | Intermediates in the formation of synthetic hormones, mimic effects of thyroid hormones; little or no effect on the heart | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-10-29 | — | — | US | disclosed |
| EP-0188351-B1 | CHEMICAL COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-03-13 | — | — | EP | disclosed |
| US-4910305-A | Containing a protected 4-hydroxyphenyl | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-03-20 | — | — | US | disclosed |
| US-4826876-A | WITHOUT EFFECT ON HEART | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-05-02 | — | — | US | disclosed |
| US-4766121-A | NOT AFFECTING THE HEART | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1988-08-23 | — | — | US | disclosed |
| EP-0188351-A2 | Chemical compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |