SCHEMBL727486

SCHEMBL727486

COCNC(=O)C1C(C(=O)Nc2ccc(Br)cc2)C2CCC1C21CC1

nearest known ligand 0.77

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 19/20 0.77
FPR3 P25089 10/20 0.77
FPR1 P21462 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL727090 0.87 FPR2 (1.00) FPR2FPR3FPR1
SCHEMBL9986557 0.87 FPR2 (1.00) FPR2FPR3FPR1
SCHEMBL2681829 0.87 FPR2 (1.00) FPR2FPR3FPR1
SCHEMBL727350 0.85 FPR2 (0.78) FPR2FPR3FPR1
SCHEMBL2683245 0.85 FPR2 (0.78) FPR2FPR3FPR1
SCHEMBL856822 0.85 FPR2 (0.78) FPR2FPR3FPR1
SCHEMBL9985206 0.84 FPR2 (0.75) FPR2FPR3FPR1
SCHEMBL728813 0.84 FPR2 (0.75) FPR2FPR3FPR1
SCHEMBL9985565 0.83 FPR2 (0.87) FPR2FPR3FPR1
SCHEMBL728721 0.83 FPR2 (0.87) FPR2FPR3FPR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011163502-A1 DERIVATIVES OF CYCLOALKYL- AND CYCLOALKENYL-1,2-DICARBOXYLIC ACID COMPOUNDS HAVING FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) AGONIST OR ANTAGONIST ACTIVITY ALLERGAN, INC. (US) 2011-12-29 WO disclosed
US-20110319454-A1 DERIVATIVES OF CYCLOALKYL- AND CYCLOALKENYL-1,2-DICARBOXYLIC ACID COMPOUNDS HAVING FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) AGONIST OR ANTAGONIST ACTIVITY ALLERGAN, INC. (US) 2011-12-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110319454-A1 DERIVATIVES OF CYCLOALKYL- AND CYCLOALKENYL-1,2-DICARBOXYLIC ACID COMPOUNDS HAVING FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) AGONIST OR ANTAGONIST ACTIVITY FPR1, FPR2, FPR3 FPR2 2/4885FPR3 3/4885FPR1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.