Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GALR2 | O43603 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3179969 | 0.71 | NOS3 (0.39) | — | |
| SCHEMBL9662788 | 0.70 | CYP2C9 (0.48) | HSD17B10ALDH1A1POLBSMN1; SMN2MITF | |
| SCHEMBL9494042 | 0.69 | LMNA (0.50) | ADCY8HSD17B10ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL27299051 | 0.68 | KMT2A (0.49) | HSD17B10PDE10AMAPK1ALDH1A1POLB | |
| SCHEMBL9651921 | 0.64 | PGK1 (0.43) | PGK1HSD17B10MAPK1ALDH1A1POLB | |
| SCHEMBL17682674 | 0.64 | POLB (0.45) | ADCY8HSD17B10ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL8882495 | 0.63 | ALDH1A1 (0.53) | HSD17B10MAPK1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL10393720 | 0.63 | PGK1 (0.42) | PGK1ADCY8ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL26688874 | 0.62 | CNKSR1 (0.39) | ALDH1A1SMN1; SMN2NPSR1RAB9AKMT2A | |
| SCHEMBL13812018 | 0.62 | CYP2C19 (0.49) | HSD17B10MAPK1ALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516392-B1 | Naphthyridine derivatives as angiotensin II inhibitors | ASTRAZENECA AB (SE) | 2001-08-29 | — | — | EP | disclosed |
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0516392-A2 | Naphthyridine derivatives as angiotensin II inhibitors | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | disclosed |