Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MMP3 | P08254 | 5/20 | 0.47 |
| ▸ | MMP1 | P03956 | 4/20 | 0.47 |
| ▸ | MMP2 | P08253 | 4/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268082 | 1.00 | CTSS (0.51) | CTSSALDH1A1MMP3MMP1MMP2 | |
| SCHEMBL8334687 | 0.80 | CTSS (0.56) | CTSSALDH1A1MMP3MMP1MMP2 | |
| SCHEMBL5528235 | 0.75 | CTSL (0.71) | CTSSALDH1A1CTSLCTSKL3MBTL1 | |
| SCHEMBL7046489 | 0.75 | ALDH1A1 (0.56) | CTSSALDH1A1CTSLSMN1; SMN2POLB | |
| SCHEMBL12823958 | 0.73 | CTSL (0.57) | CTSSALDH1A1MMP3MMP1MMP2 | |
| SCHEMBL272046 | 0.73 | CTSL (0.57) | CTSSALDH1A1MMP3MMP1MMP2 | |
| SCHEMBL7312766 | 0.73 | ALDH1A1 (0.50) | CTSSALDH1A1MMP1MMP2HPGD | |
| SCHEMBL7307705 | 0.72 | ATM (0.42) | CTSSALDH1A1CTSLCTSKHPGD | |
| SCHEMBL7307699 | 0.72 | ATM (0.42) | CTSSALDH1A1CTSLCTSKHPGD | |
| SCHEMBL5528233 | 0.72 | CTSS (0.58) | CTSSALDH1A1CTSLCTSKHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459131-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1995-10-17 | — | — | US | disclosed |
| US-5189023-A | Hypotensive agent | AMERICAN CYANAMID COMPANY (US) | 1993-02-23 | — | — | US | disclosed |
| US-5106835-A | Hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-04-21 | — | — | US | disclosed |
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |