Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275310 | 0.81 | LMNA (0.47) | F13A1TGM2TGM1MEN1KMT2A | |
| SCHEMBL11385199 | 0.78 | ALDH1A1 (0.43) | MEN1KMT2AATML3MBTL1ALDH1A1 | |
| SCHEMBL1042317 | 0.77 | F13A1 (0.47) | F13A1TGM2TGM1CCR6PAX8 | |
| SCHEMBL2347168 | 0.76 | ALDH1A1 (0.43) | MEN1KMT2AATML3MBTL1ALDH1A1 | |
| SCHEMBL6647016 | 0.75 | CCR6 (0.48) | F13A1TGM2TGM1MEN1KMT2A | |
| SCHEMBL8795201 | 0.73 | GAA (0.45) | MEN1KMT2AATML3MBTL1ALDH1A1 | |
| SCHEMBL7901531 | 0.73 | METAP2 (0.42) | MEN1KMT2AL3MBTL1ALDH1A1LMNA | |
| SCHEMBL7780922 | 0.73 | LMNA (0.50) | F13A1TGM2TGM1ALDH1A1LMNA | |
| SCHEMBL21235957 | 0.72 | CCR6 (0.48) | F13A1TGM2TGM1KMT2ACCR6 | |
| SCHEMBL8459792 | 0.72 | ALDH1A1 (0.44) | MEN1KMT2AATML3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268148-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| EP-0268148-A1 | Tetrahydronaphthalene derivatives and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-05-25 | — | — | EP | disclosed |