Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284863 | 0.81 | REN (0.51) | RENCAPN1CTSLCTSBCTSK | |
| SCHEMBL7284859 | 0.81 | REN (0.51) | RENCAPN1CTSLCTSBCTSK | |
| SCHEMBL7269371 | 0.80 | REN (0.51) | RENCAPN1CTSLCTSB | |
| SCHEMBL7269368 | 0.80 | REN (0.51) | RENCAPN1CTSLCTSB | |
| SCHEMBL9725737 | 0.79 | REN (0.50) | RENCAPN1CTSLCTSBCTSK | |
| SCHEMBL7275371 | 0.79 | REN (0.50) | RENCAPN1CTSLCTSBHTRA1 | |
| SCHEMBL9725771 | 0.77 | REN (0.47) | RENCAPN1CTSLCTSBCTSK | |
| SCHEMBL9725765 | 0.74 | CTSL (0.47) | RENCTSLCTSBCTSK | |
| SCHEMBL7269828 | 0.74 | REN (0.61) | RENCTSBCTSK | |
| SCHEMBL7275145 | 0.72 | REN (0.47) | RENBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |