Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268014 | 0.86 | CA9 (0.39) | MAPTSMN1; SMN2NPC1RAB9AGFER | |
| SCHEMBL17991465 | 0.79 | ALDH1A1 (0.41) | MAPTSMN1; SMN2RAB9ACA9GAA | |
| SCHEMBL9642249 | 0.79 | FABP6 (0.38) | MAPTCA9GAAKDM4ENPSR1 | |
| SCHEMBL323313 | 0.73 | GAA (0.60) | MAPTGAANPSR1KMT2AMEN1 | |
| SCHEMBL29358961 | 0.73 | GAA (0.60) | MAPTGAANPSR1KMT2AMEN1 | |
| SCHEMBL9642426 | 0.72 | — | — | |
| SCHEMBL30879514 | 0.70 | ALOX5 (0.46) | MAPTSMN1; SMN2NPC1RAB9AGFER | |
| SCHEMBL1448832 | 0.70 | ALOX5 (0.46) | MAPTSMN1; SMN2NPC1RAB9AGFER | |
| SCHEMBL38660914 | 0.70 | ALOX5 (0.46) | MAPTSMN1; SMN2NPC1RAB9AGFER | |
| SCHEMBL9559274 | 0.69 | MAPT (0.41) | MAPTSMN1; SMN2NPC1RAB9ACA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963677-A | TREATMENT OF CONGESTIVE HEART FAILURE | ORION CORPORATION LTD. (FI) | 1990-10-16 | — | — | US | disclosed |
| EP-0322746-A1 | Heterocyclic compounds | ORION CORPORATION LIMITED (FI) | 1989-07-05 | — | — | EP | disclosed |