Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.63 |
| ▸ | AR | P10275 | 6/20 | 0.57 |
| ▸ | P4HB | P07237 | 2/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | GYS1 | P13807 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL524173 | 0.87 | P4HB (0.56) | KIF11ARP4HBHSD17B1HSD17B2 | |
| SCHEMBL1938893 | 0.83 | HSD17B1 (0.65) | KIF11ARHSD17B1HSD17B2PGR | |
| SCHEMBL29485676 | 0.83 | HSD17B1 (0.65) | KIF11ARHSD17B1HSD17B2PGR | |
| SCHEMBL397926 | 0.81 | KIF11 (0.65) | KIF11ARMMP3PGRPTPN5 | |
| SCHEMBL4049024 | 0.79 | KIF11 (0.63) | KIF11ARMMP3PGRPTPN5 | |
| SCHEMBL27546220 | 0.78 | HSD17B1 (0.60) | KIF11ARHSD17B1HSD17B2MMP3 | |
| SCHEMBL9063141 | 0.77 | KIF11 (0.59) | KIF11ARP4HBHSD17B1HSD17B2 | |
| SCHEMBL2786052 | 0.77 | KIF11 (0.59) | KIF11ARP4HBHSD17B1HSD17B2 | |
| SCHEMBL7283993 | 0.76 | KIF11 (0.58) | KIF11ARPGR | |
| SCHEMBL28668535 | 0.75 | KIF11 (0.57) | KIF11ARP4HBPGRPTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |