Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | POLA1 | P09884 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6972258 | 0.98 | LMNA (0.43) | ALDH1A1LMNAGRIK1GRIK2TSHR | |
| Leucine SCHEMBL27517916 | 0.84 | SLC7A5 (0.51) | ALDH1A1LMNAGRIK1GRIK2SLC1A1 | |
| SCHEMBL7347073 | 0.81 | GAA (0.40) | ALDH1A1GRIK1GRIK2TSHRHSD17B10 | |
| SCHEMBL11373754 | 0.81 | ALDH1A1 (0.46) | ALDH1A1LMNATSHRHSD17B10MGAM | |
| SCHEMBL2589071 | 0.80 | TSHR (0.48) | ALDH1A1LMNATSHRHSD17B10MGAM | |
| SCHEMBL5197682 | 0.79 | HDAC3 (0.40) | ALDH1A1LMNAGRIK1GRIK2TSHR | |
| Hydrochloric Acid SCHEMBL6783166 | 0.78 | TSHR (0.46) | ALDH1A1LMNATSHRHSD17B10MGAM | |
| SCHEMBL976764 | 0.78 | ALDH1A1 (0.46) | ALDH1A1LMNATSHRHSD17B10MGAM | |
| SCHEMBL18076264 | 0.78 | ALDH1A1 (0.46) | ALDH1A1LMNATSHRHSD17B10MGAM | |
| SCHEMBL3186126 | 0.78 | ALDH1A1 (0.46) | ALDH1A1LMNATSHRHSD17B10MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481522-B1 | Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1997-12-29 | — | — | EP | disclosed |
| US-5527795-A | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-18 | — | — | US | disclosed |
| US-5491143-A | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5430145-A | Analgesics, reduction of drug withdrawal symptoms, hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-07-04 | — | — | US | disclosed |
| EP-0481522-A1 | Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1992-04-22 | — | — | EP | disclosed |