Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | ACACB | O00763 | 6/20 | 0.40 |
| ▸ | ACACA | Q13085 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272709 | 0.92 | SIGMAR1 (0.38) | SIGMAR1ACACBACACADRD2DRD3 | |
| SCHEMBL7284329 | 0.91 | ACACB (0.41) | SIGMAR1ACACBACACAKDM4EPKM | |
| SCHEMBL8881851 | 0.90 | SIGMAR1 (0.38) | SIGMAR1ACACBACACADRD2DRD3 | |
| SCHEMBL7273654 | 0.88 | SIGMAR1 (0.44) | SIGMAR1DRD2DRD3OPRM1NAMPT | |
| SCHEMBL7280539 | 0.87 | SIGMAR1 (0.44) | SIGMAR1ACACBACACADRD2DRD3 | |
| SCHEMBL7283282 | 0.85 | KDM4E (0.41) | SIGMAR1DRD2KDM4EPKMHTR1A | |
| SCHEMBL7274101 | 0.84 | ITGB3 (0.41) | SIGMAR1ACACBACACAOPRM1NAMPT | |
| SCHEMBL7304783 | 0.83 | SIGMAR1 (0.39) | SIGMAR1DRD2KDM4EPKMDRD3 | |
| SCHEMBL7271758 | 0.82 | SIGMAR1 (0.38) | SIGMAR1ACACBACACAHTR1AOPRM1 | |
| SCHEMBL7272740 | 0.81 | SIGMAR1 (0.37) | SIGMAR1DRD2DRD3NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |