Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273654 | 0.93 | SIGMAR1 (0.44) | SIGMAR1DRD2DRD3NAMPTNPC1 | |
| SCHEMBL7272424 | 0.91 | SIGMAR1 (0.45) | SIGMAR1DRD2HTR1ANAMPTACACB | |
| SCHEMBL7276136 | 0.87 | SIGMAR1 (0.40) | SIGMAR1DRD2DRD3HTR1ANAMPT | |
| SCHEMBL7283982 | 0.86 | SIGMAR1 (0.43) | SIGMAR1NAMPTACACBFAAH | |
| SCHEMBL7272709 | 0.85 | SIGMAR1 (0.38) | SIGMAR1DRD2DRD3HTR1ANAMPT | |
| SCHEMBL7304783 | 0.84 | SIGMAR1 (0.39) | SIGMAR1DRD2DRD3FAAH | |
| SCHEMBL7274528 | 0.84 | SIGMAR1 (0.45) | SIGMAR1NAMPTNPC1RAB9A | |
| SCHEMBL7280624 | 0.83 | SIGMAR1 (0.45) | SIGMAR1NAMPTFAAH | |
| SCHEMBL7274557 | 0.83 | SIGMAR1 (0.44) | SIGMAR1ACACB | |
| SCHEMBL7275472 | 0.82 | SIGMAR1 (0.41) | SIGMAR1DRD2DRD3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5621103-A | 3-(SUBSTITUTED METHYLAMINOCARBONYL)-1,2,3,4-TETRAHYDRO-(1)BENZOTHIENO(2,3-C) PYRIDINES; ANXIOLYTIC AGENTS; LEARNING ENHANCEMENT | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |