Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.64 |
| ▸ | ACHE | P22303 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267603 | 0.86 | IGF1R (0.66) | IGF1RACHEMEN1KMT2AOPRM1 | |
| SCHEMBL7267783 | 0.85 | IGF1R (0.64) | IGF1RACHEMEN1KMT2AOPRM1 | |
| Water SCHEMBL7275823 | 0.84 | IGF1R (0.63) | IGF1RACHEMEN1KMT2AOPRM1 | |
| SCHEMBL14355260 | 0.81 | IGF1R (0.60) | IGF1RACHEMEN1KMT2AOPRM1 | |
| SCHEMBL7435733 | 0.81 | IGF1R (0.60) | IGF1RACHEMEN1KMT2AOPRM1 | |
| SCHEMBL7290611 | 0.80 | ACHE (0.61) | IGF1RACHEMEN1KMT2AOPRM1 | |
| SCHEMBL9254406 | 0.80 | ACHE (0.73) | IGF1RACHEMEN1KMT2AOPRM1 | |
| SCHEMBL7439416 | 0.79 | IGF1R (0.57) | IGF1RACHEMEN1KMT2AOPRM1 | |
| SCHEMBL7446980 | 0.78 | IGF1R (0.56) | IGF1RACHEMEN1KMT2AOPRM1 | |
| SCHEMBL7754375 | 0.77 | IGF1R (0.55) | IGF1RACHEMEN1KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252569-A | Cardiotonic, antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0331511-B1 | 6-SUBSTITUTED PURINYL PIPERAZINE DERIVATIVES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5164390-A | Cardiac disorders | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0458618-A1 | 6-Substituted purinyl piperazine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-11-27 | — | — | EP | disclosed |
| US-5021574-A | Cardiotonic agents, antiarrhythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-06-04 | — | — | US | disclosed |
| US-5001127-A | 4-substituted pyrazolo[3,4-d]pyrimidine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-03-19 | — | — | US | disclosed |
| US-4885300-A | CARDIOTONIC AND ANTIARRHYTHMIA AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-12-05 | — | — | US | disclosed |
| US-4876257-A | 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-10-24 | — | — | US | disclosed |
| EP-0331511-A1 | 6-Substituted purinyl piperazine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-09-06 | — | — | EP | disclosed |
| EP-0331510-A2 | 4-Substituted pyrazolo[3,4-d]pyrimidine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-09-06 | — | — | EP | disclosed |