Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435733 | 0.85 | IGF1R (0.60) | IGF1RACHEDRD2OPRM1CACNA1B | |
| SCHEMBL7439416 | 0.83 | IGF1R (0.57) | IGF1RACHEDRD2OPRM1CACNA1B | |
| SCHEMBL14355260 | 0.83 | IGF1R (0.60) | IGF1RACHEDRD2OPRM1CACNA1B | |
| SCHEMBL8612635 | 0.81 | CYP2D6 (0.50) | IGF1RACHEDRD2OPRM1CACNA1B | |
| SCHEMBL7267603 | 0.79 | IGF1R (0.66) | IGF1RACHEDRD2OPRM1CACNA1B | |
| SCHEMBL7754375 | 0.79 | IGF1R (0.55) | IGF1RACHEDRD2OPRM1CACNA1B | |
| SCHEMBL7267783 | 0.78 | IGF1R (0.64) | IGF1RACHEDRD2OPRM1CACNA1B | |
| SCHEMBL7276482 | 0.78 | IGF1R (0.64) | IGF1RACHEDRD2OPRM1CACNA1B | |
| Hydrochloric Acid SCHEMBL7548578 | 0.78 | IGF1R (0.54) | IGF1RACHEDRD2OPRM1CACNA1B | |
| Water SCHEMBL7275823 | 0.77 | IGF1R (0.63) | IGF1RACHEDRD2OPRM1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5001127-A | 4-substituted pyrazolo[3,4-d]pyrimidine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-03-19 | — | — | US | disclosed |