Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435733 | 0.86 | IGF1R (0.60) | IGF1RACHEDRD2HTR1AHTR7 | |
| SCHEMBL7446980 | 0.83 | IGF1R (0.56) | IGF1RACHEDRD2HTR1AHTR7 | |
| SCHEMBL8612798 | 0.83 | IGF1R (0.53) | IGF1RDRD2HTR1AHTR7MEN1 | |
| SCHEMBL7267603 | 0.80 | IGF1R (0.66) | IGF1RACHEDRD2HTR1AHTR7 | |
| SCHEMBL7754375 | 0.80 | IGF1R (0.55) | IGF1RACHEDRD2HTR1AHTR7 | |
| SCHEMBL7267783 | 0.79 | IGF1R (0.64) | IGF1RACHEDRD2HTR1AHTR7 | |
| SCHEMBL7276482 | 0.79 | IGF1R (0.64) | IGF1RACHEDRD2HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL7548578 | 0.79 | IGF1R (0.54) | IGF1RACHEDRD2HTR1AHTR7 | |
| SCHEMBL14355260 | 0.78 | IGF1R (0.60) | IGF1RACHEDRD2MEN1KMT2A | |
| Water SCHEMBL7275823 | 0.78 | IGF1R (0.63) | IGF1RACHEDRD2HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164390-A | Cardiac disorders | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-11-17 | — | — | US | disclosed |
| US-5021574-A | Cardiotonic agents, antiarrhythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-06-04 | — | — | US | disclosed |
| US-5001127-A | 4-substituted pyrazolo[3,4-d]pyrimidine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-03-19 | — | — | US | disclosed |