Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825822 | 0.76 | LMNA (0.43) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11097773 | 0.72 | CHEK1 (0.46) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9360294 | 0.72 | NPC1 (0.49) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL19935423 | 0.66 | CBFB (0.47) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| Dipyridyl SCHEMBL27763611 | 0.66 | KDM4E (0.78) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4777973 | 0.63 | KDM4E (0.50) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| Dipyridyl SCHEMBL5974690 | 0.62 | KDM4E (0.70) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| Dipyridyl SCHEMBL2026660 | 0.62 | KDM4E (0.70) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| Dipyridyl SCHEMBL28457942 | 0.62 | KDM4E (0.70) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL22274797 | 0.62 | L3MBTL1 (0.56) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539575-B1 | INHIBITION OF METASTASIS IN PATIENTS HAVING CANCER WITH PYRIDYLOXAZOLE-2-ONES | MERRELL PHARMA INC (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5610171-A | Inhibition of metastasis in patients having cancer with pyridyloxazole-2-ones | MERRELL PHARMACEUTICALS INC. (US) | 1997-03-11 | — | — | US | disclosed |
| WO-1993010778-A1 | INHIBITION OF ANGIOGENESIS WITH PYRIDINYLOXAZOLE-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-10 | — | — | WO | disclosed |
| US-5182293-A | Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-01-26 | — | — | US | disclosed |
| US-5063238-A | Kinase inhibitor | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-11-05 | — | — | US | disclosed |
| EP-0428106-A1 | Novel pyridyloxazole 2-ones useful as proteinkinase C inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0428104-A2 | Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0428103-A2 | Prevention of glycoprotein enveloped virus infectivity by pyridyloxazole-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-05-22 | — | — | EP | disclosed |